Anti-inflammatory and gastro protective activity of sigoise olive leaves extracts from Algeria: in vivo and in silico evidence

Authors

  • Sarra Metlef Laboratory of Bioresources. Nutition and food sciences department. Faculty of Nature and Life Sciences. University Hassiba Benbouali of Chlef, Algeria
  • Azdinia Zidane Laboratory of Bioresources. Department of Biology. Faculty of Nature and Life Sciences. University Hassiba Benbouali of Chlef, Algeria
  • Meriem Saadoud Laboratory of Beneficial Microorganisms, Functional Food and Health, department of Nutrition and food sciences. Faculty of Nature and Life Sciences. University Hassiba Benbouali of Chlef, Algeria
  • Leila Gadouche Laboratory of Bioresources. Department of Biology. Faculty of Nature and Life Sciences. University Hassiba Benbouali of Chlef, Algeria

Abstract

The number of inflammatory diseases and gastric pathologies is continuously increasing, secondary effects of synthetic drugs have led researchers to focus on compounds of vegetable origin, of which olive leaves are part. In this context our study aims to evaluate some biological activities ( anti-inflammatory and gastroprotective) of Algerian Sigoise extracts of olive leaves in vivo and in silico using molecular docking modeling. The anti-inflammatory activity of olive leaves extracts was highly significant, with an inhibition percentage of inflammation of 79%, close to that of the reference drug ibuprofen (82%). The in silico study showed a high affinity between oleocanthal , hydroxyterosol and tyrosol of sigoise olive leafs  with COX-2 where the recorded interaction energies were of the order of -7.1 kcal/mol,  -4.9 k cal/mol and -3.4 kcal/mol respectively. These values are relatively close to that of ibuprofen (G = -8.2 kcal/mol). The interaction energy of COX-2 with its reference ligand SC-588 is equal to -10.1 kcal/mol, the lowest RMSD values (1.02) was recorded with oleacanthal. At the same way, olive leaves extract have a gastroprotective activity wich was manifested by the protection of  rats stomachs against ethanol alterations. This was clearly demonstrated by ANAPATH, which showed that the tissues of the stomachs treated with the extracts were not ulcerated and was similaire to those treated with drugs and even those of controls.

Published

16-10-2024

How to Cite

Metlef , S., Zidane , A., Saadoud , M., & Gadouche , L. (2024). Anti-inflammatory and gastro protective activity of sigoise olive leaves extracts from Algeria: in vivo and in silico evidence. 7th International Anatolian Agriculture, Food, Environment and Biology Congress, Kastamonu/Türkiye, 6–6. from http://targid.org/index.php/TURSTEP/article/view/308